Concise reports
Urinary albumin excretion in patients with systemic lupus
erythematosus without renal disease
a Department of
Rheumatology and University of Alicante, Hospital General Universitario
de Alicante, Alicante, Spain , b Department of Clinical
Analysis, Hospital General Universitario de Alicante, Alicante, Spain
Correspondence to: Dr E Batlle-Gualda, Sección de Reumatología, Hospital General Universitario de Alicante, Calle Maestro Alonso, 109 03010, Alicante, Spain.
Accepted for publication 26 March
1997
OBJECTIVES
To investigate the prevalence of
microalbuminuria, urinary albumin excretion (UAE) between 20-200 µg/min, in systemic lupus erythematosus (SLE) patients without
clinical renal disease, and to discover if this could predict the
development of renal disease.
METHODSThis study made six monthly measurements
of UAE, creatinine clearance, serological and clinical data in 22 ambulatory women patients with SLE, without clinical renal disease,
hypertension, diabetes or heart failure. The patients were followed up
for a period of 18 months (four measurements). Age and sex matched
healthy controls were used as a comparative group. UAE was measured by nephelometry in three timed overnight urine samples at each visit.
RESULTSThere were no significant differences in
the creatinine clearance between the control group and the SLE
patients. Creatinine clearance did not show significant changes
throughout the study period. SLE patients had wide variations in the
UAE rate compared with healthy controls. In five patients (5 of 22;
23%), on occasions, there was mild, transient increase in UAE reaching
the level of microalbuminuria. During follow up, one patient with basal
(4.67 µg/min) and six month (4.73 µg/min) normal UAE rate, was
admitted with a nephrotic syndrome confirmed on biopsy examination to
be proliferative lupus nephritis. Six months after beginning treatment with prednisone and cyclophosphamide her UAE rate returned to normal
values (4.65 µg/min).
CONCLUSIONSLE patients without clinical renal
disease may have microalbuminuria, although this does not seem to
warrant any specific action.
© 1997 by Annals of the Rheumatic Diseases
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(2001). Metabolic abnormalities associated with microalbuminuria in systemic lupus erythematosus. Rheumatology (Oxford)
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