Concise reports
Subgroups of primary Sjögren's syndrome. Sjögren's syndrome
in male and paediatric Greek patients
a Departments of Internal Medicine , b and Paediatrics , c Medical School, University of
Ioannina, Ioannina, Greece
Correspondence to: Dr A A Drosos, Department of Internal Medicine, Medical School,University of Ioannina, 45110 Ioannina, Greece.
Accepted for publication 14 February 1997
OBJECTIVES
To describe the clinical and
serological findings in male and paediatric Sjögren's syndrome (SS) patients.
PATIENTS AND METHODSUsing the European criteria
for the diagnosis of SS 12 male and 13 paediatric patients were
identified and compared with those of 30 consecutive unselected adult
female SS patients.
RESULTSThe mean (SD) age of paediatric patients
was 9.4 (2.2) years, ranging from 6 to 14 years. Recurrent parotid
gland enlargement was the initial clinical manifestation in the
majority of the children with a statistical significance compared with
male (p<0.01) and with female patients (p<0.0001). Sicca
manifestations were the most common clinical symptoms in male and
female patients at disease onset. The systemic manifestations were
similar among the three groups except that men showed lower frequency
of arthritis (p<0.05) and Raynaud's phenomenon (p<0.05) compared
with women. No differences were found among the immunological profile
of children and female patients, while male patients had a lower
frequency of antinuclear antibodies (p<0.025) and antibodies to
Ro(SSA) nuclear antigens (p<0.025) compared with women.
CONCLUSIONPrimary SS is rare in children and
men in Greece. Recurrent parotid gland enlargement is the most common
clinical finding at disease onset in children. Male patients seem to
have less systemic manifestations and lower frequency of autoantibodies.
© 1997 by Annals of the Rheumatic Diseases
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