Sister chromatid exchange analysis in the lymphocytes of patients with ankylosing spondylitis

doi:10.1136/ard.56.4.275

Annals of the Rheumatic Diseases 1997;56:275-277; doi:10.1136/ard.56.4.275

Ann Rheum Dis 1997;56:275-277 ( April )

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Sister chromatid exchange analysis in the lymphocytes of patients with ankylosing spondylitis Sinan Sönmez,^a Kaz $i$ m enel,^b S $i$ tk $i$ Özta $s$ ,^a Ak $i$ n Erdal,^b Lale Cerraho $g$ lu^b

^a Departments of Medical Genetics , ^b and Physical Medicine and Rehabilitation , ^c Atatürk University Faculty of Medicine, Erzurum, Turkey

Correspondence to: Dr S Sönmez, Atatürk Universitesi Tip Fakültesi Tibbi Genetik Anabilim Dali, 25240 Erzurum, Turkey.

Accepted for publication 9 December 1996

OBJECTIVE $---$ This study investigated whether any genomic change occurs in DNA level in ankylosing spondylitis (AS) by measuring sisterchromatid exchange (SCE)frequency.
METHODS $---$ SCE frequency was detected on metaphase chromosomes obtained from peripheral blood lymphocyte cultures in 15 patients diagnosedas having AS. SCE values were also obtained from 15 healthy subjectsas a control group. SCE frequencies were detected from metaphasesobtained from standard blood cultures by using bromodeoxyuridineand staining byGiemsa.
RESULTS $---$ SCE frequencies of AS were statistically higher than those of the control group (p<0.005).
CONCLUSION $---$ These results suggest that genetic factors may play a more important part than realised in the aetiology ofAS.

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