Extended reports
Assessment of anti-endothelial cell antibodies in systemic
sclerosis and Sjögren's syndrome
Departments of Internal Medicine (CHRU),
Pathology C (CHRU), and Immunology (Unité INSERM 416, Institut
Pasteur), Lille, France
Correspondence to: Dr M Hebbar, Service de Médecine Interne A, Hôpital Huriez, CHRU, 1 place de Verdun, 59037 Lille Cedex, France.
Accepted for publication 2 January 1997
OBJECTIVES
Anti-endothelial cell antibodies
(AECA) have been detected in 19 to 30% of patients with systemic
sclerosis (SSc). The objective of this study was first to assess the
role of a secondary Sjögren's syndrome (SS) in the occurrence of
AECA in SSc. Secondly, we researched AECA in patients with primary SS,
and investigated whether AECA were associated with vascular
manifestations (Raynaud's phenomenon and vasculitis).
METHODSIgG-AECA were tested by an ELISA method
in serum samples from 50 patients with SSc (16 of them had also a
secondary SS), 50 patients with primary SS, and 50 healthy controls.
RESULTSAECA levels were significantly higher in
patients with SSc or primary SS than in healthy controls (p < 0.01 and
p < 0.01, respectively). In patients with SSc, AECA values were
significantly higher in patients with secondary SS (p < 10
5). In patients with primary SS, AECA levels were
significantly higher in patients with Raynaud's phenomenon (p < 0.01), but not in patients with vasculitis.
CONCLUSIONIn patients with SSc, AECA are
associated with a secondary SS. In patients with primary SS, AECA are
associated with Raynaud's phenomenon, but not with vasculitis.
© 1997 by Annals of the Rheumatic Diseases
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