Detection of oncostatin M in synovial fluid from patients with rheumatoid arthritis

doi:10.1136/ard.56.3.184

Annals of the Rheumatic Diseases 1997;56:184-187; doi:10.1136/ard.56.3.184

Ann Rheum Dis 1997;56:184-187 ( March )

Concise reports

Detection of oncostatin M in synovial fluid from patients with rheumatoid arthritis Wang Hui, Michael Bell, Graeme Carroll

Department of Rheumatology and The Research Centre, Royal Perth Hospital,Perth, Western Australia, Australia

Correspondence to: Dr G Carroll, Department of Rheumatology and The Research Centre, Royal Perth Hospital, Perth, Western Australia, Australia.

Accepted for publication 13 December 1996

OBJECTIVE $---$ To measure oncostatin M (OSM) in synovial fluid from patients with rheumatoid arthritis (RA) and osteoarthritis(OA).
METHODS $---$ 20 samples of synovial fluid from patients with RA and 10 samples from patients with OA were examined using an OSM specificsandwichELISA.
RESULTS $---$ OSM was detected at concentrations ranging from 2.36 to 901.82 pg/ml in 18 (90%) of 20 samples of synovial fluid from RA patients.There was no detectable OSM in synovial fluid from OA patients.In the RA patients, the OSM concentration in synovial fluid correlatedsignificantly with the synovial fluid white blood cell count (r=0.67,p<0.01), but not with other laboratory parameters of diseaseactivity.
CONCLUSION $---$ These findings suggest that OSM may contribute to joint inflammation inRA.

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