Extended reports
Cartilage and bone macromolecules in knee joint synovial fluid in
rheumatoid arthritis: relation to development of knee or hip joint
destruction
Department of Rheumatology, Lund University,
Lund, Sweden
Correspondence to: Dr Tore Saxne, Department of Rheumatology, Lund University Hospital, S-221 85, Lund, Sweden.
Accepted for publication 7 November 1996
OBJECTIVE
To examine the hypothesis that
aggrecan, cartilage oligomeric matrix protein (COMP), and bone
sialoprotein (BSP) concentrations in synovial fluid could provide
information on variations of progression of joint destruction in
rheumatoid arthritis.
METHODSAggrecan, COMP, and BSP were quantified
by enzyme linked immunosorbent assays in longitudinally collected knee
joint synovial fluid samples of patients rapidly developing destruction
in knees or hips, the "destructive" group, n = 18, and in patients
slowly developing destruction, the "non-destructive" group, n = 25.
RESULTSThe aggrecan concentrations decreased
from initially high levels (P << 0.001), and the BSP concentrations
increased (P << 0.001) over time in the destructive group, whereas
levels of both markers were low and did not change in the
non-destructive group. The COMP levels did not change in any of the
groups. The aggrecan concentrations were initially highest in the group
developing destructions (P << 0.001), whereas no difference between
the groups was found regarding levels of COMP or BSP in the first sample.
CONCLUSIONSA destructive group was characterised
by higher initial aggrecan concentrations and rising BSP concentrations
in synovial fluid with time. Quantification of cartilage and bone
derived macromolecules contributes to the assessment of extent of
tissue destruction and may help in the early identification of patients at risk of rapidly progressing destruction.
© 1997 by Annals of the Rheumatic Diseases
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