Characterisation of follicular dendritic cells in labial salivary glands of patients with primary Sjogren syndrome: comparison with tonsillar lymphoid follicles

doi:10.1136/ard.56.2.140

Annals of the Rheumatic Diseases 1997;56:140-143; doi:10.1136/ard.56.2.140

Ann Rheum Dis 1997;56:140-143 ( February )

Concise reports

Characterisation of follicular dendritic cells in labial salivary glands of patients with primary Sjogren syndrome: comparison with tonsillar lymphoid follicles Karim Elias Aziz, Peter J McCluskey, Denis Wakefield

School of Pathology, University of New South Wales, Australia

Correspondence to: Dr K E Aziz and Denis Wakefield, Immunopathology Department, PO Box 649, Caringbah, NSW 2229, Australia.

Accepted for publication 17 October 1996

OBJECTIVE $---$ To localise and characterise follicular dendritic cells (FDC) present in autoimmune lesions of primary Sjogrensyndrome.
METHODS $---$ Cryostat sections of labial salivary glands from 15 patients with primary Sjogren syndrome were examined by an indirect immunoperoxidasetechnique and monoclonal antibodies to a panel of dendritic cellmarkers. Tonsils from two controls were also examined for thesamemarkers.
RESULTS $---$ FDC were localised in the centre of 75% of lymphoid focal structures in labial salivary gland biopsies. FDC in labial salivaryglands of patients with primary Sjogren syndrome expressed CD35,CD11c, and CD106 (VCAM-1) in a pattern similar to FDC in tonsils,but they did not express either CD14 or CD11b. This indicatesthat they may not be of myeloid origin, while FDC in tonsillarlymphoid follicles strongly expressed both CD14 and CD11b. FDCin labial salivary glands of patients also lacked VLA-2 $alpha$ and VLA-3 $alpha$ ,which were expressed by FDC intonsils.
CONCLUSIONS $---$ The characteristic phenotype and origin of these cells may be of importance in the immune responses involved in Sjogren syndromeand the retention of infiltrating lymphocytes in theglands.

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