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Fasting enhances mucosal antigen specific B cell responses in
rheumatoid arthritis
Departments of Rheumatology and Clinical
Immunology, University of Göteborg, Göteborg, Sweden
Correspondence to: C Trollmo, Department of Rheumatology, Guldhedsgatan 10A, S-413 46 Göteborg, Sweden.
Accepted for publication 15 October 1996
OBJECTIVE
To evaluate the influence of fasting on
the antigen specific immune responsiveness in patients with rheumatoid
arthritis and healthy volunteers.
METHODSSeven rheumatoid arthritis patients and
17 healthy volunteers were immunised perorally or parenterally with
influenza virus vaccine after a three to six day long period of total
energy deprivation (water fast). The subsequent antigen specific
antibody mediated immune response was recorded in the blood at the
single cell level by the ELISPOT method.
RESULTSShort term starvation induced an enhanced
antigen specific mucosa derived B lymphocyte response in rheumatoid
arthritis patients and healthy volunteers. In contrast, the systemic B
cell responses were not significantly altered by a total energy deprivation.
CONCLUSIONSShort term starvation increases the
mucosa derived B cell responsiveness, while systemic responsiveness is
largely unaffected. The similar pattern of response in rheumatoid
arthritis patients and healthy volunteers indicates that fasting alters
the mucosal immune response independently of medical treatment.
© 1997 by Annals of the Rheumatic Diseases
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