Concise reports
Association between osteoarthritis of the hand and knee in a
population of skeletons from London
St Mary's Hospital,
Praed Street, London W2 1NY; Institute of Archaeology, University
College London, London WC1H 0PY, United Kingdom
Correspondence to: Dr H A Waldron, 31 Maidstone Road, London N11 2TR.
Accepted for publication 7 November 1996
OBJECTIVE
To examine the relation between
osteoarthritis of the hand and knee in a group of skeletons dating to
the 18th and early 19th centuries from two sites in London.
METHODSThis was a case-control study of 115 cases and controls matched for age and sex. Cases were skeletons with
osteoarthritis of the hands; cases and controls were assessed for the
presence of osteoarthritis of any compartment of the knee.
RESULTSCases had a significant odds ratio (OR)
for osteoarthritis of the knee compared with controls: OR 5.98, 95%
confidence interval (CI) 1.25 to 56.37. Cases with osteoarthritis of
the distal interphalangeal (DIP), proximal interphalangeal (PIP), and
first carpometacarpal (CMC1) joints had increased but non-significant
odds ratios for osteoarthritis of the knee in the order DIP > PIP > CMC1. Cases with multifocal osteoarthritis of the hands had a
significantly increased odds ratio for osteoarthritis of the knee: OR
11.67, 95% CI 1.13 to 379.57.
CONCLUSIONSThe study confirms the association
between osteoarthritis of the hand and the knee seen in contemporary
populations and suggests that it is not of very recent origin.
© 1997 by Annals of the Rheumatic Diseases
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