Concise reports
Fc
RIIa polymorphism in systemic lupus erythematosus
a ARC Epidemiology Unit, University of
Manchester, Manchester, b Departments of Immunology and
Rheumatology, Hope Hospital, Salford, c Department of Histocompatibility and Immunology, Evangelismos
Hospital, Athens, Greece
Correspondence to: Dr N Snowden, Department of Immunology, Hope Hospital, Salford M6 8HD.
Accepted for publication 22
September 1997
OBJECTIVES
Polymorphism of the phagocyte IgG
receptor Fc
RIIa may modulate immune complex mediated inflammation,
particularly when immune complexes contain IgG2. Previous studies
suggest that this polymorphism may be an important risk factor for
lupus nephritis. Fc
RIIa is biallelic, the alleles R and H each
having a gene frequency of about 50%. Nephritis has been associated
with an increased frequency of the R allele. The frequency of common
Fc
RIIa alleles was examined in white subjects from the United
Kingdom and Greek subjects with systemic lupus erythematosus (SLE) and
healthy controls.
METHODS
Fc
RIIa genotyping was performed using a
single step polymerase chain reaction technique, which differentiates
the two major alleles, R and H. Two study populations were examined:
(a) white subjects from the United Kingdom : 66 controls and 81 with
SLE (19 of whom had renal disease) and (b) Greek: 52 controls and 42 with SLE (19 with renal disease).
RESULTS
No significant relation was observed
between Fc
RIIa genotype and susceptibility to SLE or SLE nephritis.
CONCLUSIONS
The Fc
RIIa R allele does not seem
to be associated with SLE (with or without renal disease) in our United
Kingdom white or Greek populations.
© 1997 by Annals of the Rheumatic Diseases
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