|
|
||||||||||||||
|
|
|||||||||||||||
RIIa polymorphism in systemic lupus erythematosus
a ARC Epidemiology Unit, University of
Manchester, Manchester, b Departments of Immunology and
Rheumatology, Hope Hospital, Salford, c Department of Histocompatibility and Immunology, Evangelismos
Hospital, Athens, Greece
Correspondence to: Dr N Snowden, Department of Immunology, Hope Hospital, Salford M6 8HD.
Accepted for publication 22
September 1997
OBJECTIVES
Polymorphism of the phagocyte IgG
receptor Fc
RIIa may modulate immune complex mediated inflammation,
particularly when immune complexes contain IgG2. Previous studies
suggest that this polymorphism may be an important risk factor for
lupus nephritis. Fc
RIIa is biallelic, the alleles R and H each
having a gene frequency of about 50%. Nephritis has been associated
with an increased frequency of the R allele. The frequency of common
Fc
RIIa alleles was examined in white subjects from the United
Kingdom and Greek subjects with systemic lupus erythematosus (SLE) and
healthy controls.
METHODS
Fc
RIIa genotyping was performed using a
single step polymerase chain reaction technique, which differentiates
the two major alleles, R and H. Two study populations were examined:
(a) white subjects from the United Kingdom : 66 controls and 81 with
SLE (19 of whom had renal disease) and (b) Greek: 52 controls and 42 with SLE (19 with renal disease).
RESULTS
No significant relation was observed
between Fc
RIIa genotype and susceptibility to SLE or SLE nephritis.
CONCLUSIONS
The Fc
RIIa R allele does not seem
to be associated with SLE (with or without renal disease) in our United
Kingdom white or Greek populations.
This article has been cited by other articles:
![]() |
M. Mackay, A. Stanevsky, T. Wang, C. Aranow, M. Li, S. Koenig, J. V. Ravetch, and B. Diamond Selective dysregulation of the Fc{gamma}IIB receptor on memory B cells in SLE J. Exp. Med., September 4, 2006; 203(9): 2157 - 2164. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. P. Bazilio, V. S. T. Viana, R. Toledo, V. Woronik, E. Bonfa, and R. C. Monteiro Fc{gamma}RIIa polymorphism: a susceptibility factor for immune complex-mediated lupus nephritis in Brazilian patients Nephrol. Dial. Transplant., June 1, 2004; 19(6): 1427 - 1431. [Abstract] [Full Text] [PDF] |
||||
![]() |
K Manger, R Repp, M Jansen, M Geisselbrecht, R Wassmuth, N A C Westerdaal, A Pfahlberg, B Manger, J R Kalden, and J G J van de Winkel Fc{gamma} receptor IIa, IIIa, and IIIb polymorphisms in German patients with systemic lupus erythematosus: association with clinical symptoms Ann Rheum Dis, September 1, 2002; 61(9): 786 - 792. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Villarreal, D. Crosdale, W. Ollier, A. Hajeer, W. Thomson, J. Ordi, E. Balada, M. Villardell, L.-S. Teh, and K. Poulton Mannose binding lectin and Fc{gamma}RIIa (CD32) polymorphism in Spanish systemic lupus erythematosus patients Rheumatology, September 1, 2001; 40(9): 1009 - 1012. [Abstract] [Full Text] [PDF] |
||||
![]() |
H R Yun, H K Koh, S-S Kim, W T Chung, D W Kim, K P Hong, G G Song, H K Chang, J-Y Choe, S-C Bae, et al. Fc{gamma}RIIa/IIIa polymorphism and its association with clinical manifestations in Korean lupus patients Lupus, July 1, 2001; 10(7): 466 - 472. [Abstract] [PDF] |
||||
![]() |
T. Lehrnbecher, C. B. Foster, S. Zhu, S. F. Leitman, L. R. Goldin, K. Huppi, and S. J. Chanock Variant Genotypes of the Low-Affinity Fcgamma Receptors in Two Control Populations and a Review of Low-Affinity Fcgamma Receptor Polymorphisms in Control and Disease Populations Blood, December 15, 1999; 94(12): 4220 - 4232. [Abstract] [Full Text] [PDF] |
||||
![]() |
S N Yap, M E Phipps, M Manivasagar, S Y Tan, and J J Bosco Human Fc gamma receptor IIA (Fc{gamma}RIIA) genotyping and association with systemic lupus erythematosus (SLE) in Chinese and Malays in Malaysia Lupus, May 1, 1999; 8(4): 305 - 310. [Abstract] [PDF] |
||||
![]() |
M J Rood, V Keijsers, M W van der Linden, T Q T Tong, S E Borggreve, C L Verweij, F C Breedveld, and T W J Huizinga Neuropsychiatric systemic lupus erythematosus is associated with imbalance in interleukin 10 promoter haplotypes Ann Rheum Dis, February 1, 1999; 58(2): 85 - 89. [Abstract] [Full Text] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |