Ann Rheum Dis

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smyth, L J C
Right arrow Articles by Ollier, W E R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smyth, L J C
Right arrow Articles by Ollier, W E R
Ann Rheum Dis 1997;56:744-746 ( December )

Concise reports

Fcgamma RIIa polymorphism in systemic lupus erythematosus L J C Smyth,a N Snowden,b D Carthy,a C Papasteriades,c A Hajeer,a W E R Olliera

a ARC Epidemiology Unit, University of Manchester, Manchester, b Departments of Immunology and Rheumatology, Hope Hospital, Salford, c Department of Histocompatibility and Immunology, Evangelismos Hospital, Athens, Greece

Correspondence to: Dr N Snowden, Department of Immunology, Hope Hospital, Salford M6 8HD.

Accepted for publication 22 September 1997

OBJECTIVES---Polymorphism of the phagocyte IgG receptor Fcgamma RIIa may modulate immune complex mediated inflammation, particularly when immune complexes contain IgG2. Previous studies suggest that this polymorphism may be an important risk factor for lupus nephritis. Fcgamma RIIa is biallelic, the alleles R and H each having a gene frequency of about 50%. Nephritis has been associated with an increased frequency of the R allele. The frequency of common Fcgamma RIIa alleles was examined in white subjects from the United Kingdom and Greek subjects with systemic lupus erythematosus (SLE) and healthy controls.
METHODS---Fcgamma RIIa genotyping was performed using a single step polymerase chain reaction technique, which differentiates the two major alleles, R and H. Two study populations were examined: (a) white subjects from the United Kingdom : 66 controls and 81 with SLE (19 of whom had renal disease) and (b) Greek: 52 controls and 42 with SLE (19 with renal disease).
RESULTS---No significant relation was observed between Fcgamma RIIa genotype and susceptibility to SLE or SLE nephritis.
CONCLUSIONS---The Fcgamma RIIa R allele does not seem to be associated with SLE (with or without renal disease) in our United Kingdom white or Greek populations.

© 1997 by Annals of the Rheumatic Diseases


This article has been cited by other articles:


Home page
 J. Exp. Med.Home page
M. Mackay, A. Stanevsky, T. Wang, C. Aranow, M. Li, S. Koenig, J. V. Ravetch, and B. Diamond
Selective dysregulation of the Fc{gamma}IIB receptor on memory B cells in SLE
J. Exp. Med., September 4, 2006; 203(9): 2157 - 2164.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
A. P. Bazilio, V. S. T. Viana, R. Toledo, V. Woronik, E. Bonfa, and R. C. Monteiro
Fc{gamma}RIIa polymorphism: a susceptibility factor for immune complex-mediated lupus nephritis in Brazilian patients
Nephrol. Dial. Transplant., June 1, 2004; 19(6): 1427 - 1431.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
K Manger, R Repp, M Jansen, M Geisselbrecht, R Wassmuth, N A C Westerdaal, A Pfahlberg, B Manger, J R Kalden, and J G J van de Winkel
Fc{gamma} receptor IIa, IIIa, and IIIb polymorphisms in German patients with systemic lupus erythematosus: association with clinical symptoms
Ann Rheum Dis, September 1, 2002; 61(9): 786 - 792.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
J. Villarreal, D. Crosdale, W. Ollier, A. Hajeer, W. Thomson, J. Ordi, E. Balada, M. Villardell, L.-S. Teh, and K. Poulton
Mannose binding lectin and Fc{gamma}RIIa (CD32) polymorphism in Spanish systemic lupus erythematosus patients
Rheumatology, September 1, 2001; 40(9): 1009 - 1012.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
H R Yun, H K Koh, S-S Kim, W T Chung, D W Kim, K P Hong, G G Song, H K Chang, J-Y Choe, S-C Bae, et al.
Fc{gamma}RIIa/IIIa polymorphism and its association with clinical manifestations in Korean lupus patients
Lupus, July 1, 2001; 10(7): 466 - 472.
[Abstract] [PDF]

Home page
 BloodHome page
T. Lehrnbecher, C. B. Foster, S. Zhu, S. F. Leitman, L. R. Goldin, K. Huppi, and S. J. Chanock
Variant Genotypes of the Low-Affinity Fcgamma Receptors in Two Control Populations and a Review of Low-Affinity Fcgamma Receptor Polymorphisms in Control and Disease Populations
Blood, December 15, 1999; 94(12): 4220 - 4232.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
S N Yap, M E Phipps, M Manivasagar, S Y Tan, and J J Bosco
Human Fc gamma receptor IIA (Fc{gamma}RIIA) genotyping and association with systemic lupus erythematosus (SLE) in Chinese and Malays in Malaysia
Lupus, May 1, 1999; 8(4): 305 - 310.
[Abstract] [PDF]

Home page
 Ann Rheum DisHome page
M J Rood, V Keijsers, M W van der Linden, T Q T Tong, S E Borggreve, C L Verweij, F C Breedveld, and T W J Huizinga
Neuropsychiatric systemic lupus erythematosus is associated with imbalance in interleukin 10 promoter haplotypes
Ann Rheum Dis, February 1, 1999; 58(2): 85 - 89.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 1997 BMJ Publishing Group Ltd & European League Against Rheumatism