Ann Rheum Dis 1997;56:744-746 ( December )

Concise reports

FcRIIa polymorphism in systemic lupus erythematosus L J C Smyth,^a N Snowden,^b D Carthy,^a C Papasteriades,^c A Hajeer,^a W E R Ollier^a

^a ARC Epidemiology Unit, University of Manchester, Manchester, ^b Departments of Immunology and Rheumatology, Hope Hospital, Salford, ^c Department of Histocompatibility and Immunology, Evangelismos Hospital, Athens, Greece

Correspondence to: Dr N Snowden, Department of Immunology, Hope Hospital, Salford M6 8HD.

Accepted for publication 22 September 1997

OBJECTIVESPolymorphism of the phagocyte IgG receptor FcRIIa may modulate immune complex mediated inflammation, particularly when immune complexes contain IgG2. Previous studies suggest that this polymorphism may be an important risk factor for lupus nephritis. FcRIIa is biallelic, the alleles R and H each having a gene frequency of about 50%. Nephritis has been associated with an increased frequency of the R allele. The frequency of common FcRIIa alleles was examined in white subjects from the United Kingdom and Greek subjects with systemic lupus erythematosus (SLE) and healthy controls.
METHODSFcRIIa genotyping was performed using a single step polymerase chain reaction technique, which differentiates the two major alleles, R and H. Two study populations were examined: (a) white subjects from the United Kingdom : 66 controls and 81 with SLE (19 of whom had renal disease) and (b) Greek: 52 controls and 42 with SLE (19 with renal disease).
RESULTSNo significant relation was observed between FcRIIa genotype and susceptibility to SLE or SLE nephritis.
CONCLUSIONSThe FcRIIa R allele does not seem to be associated with SLE (with or without renal disease) in our United Kingdom white or Greek populations.

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© 1997 by Annals of the Rheumatic Diseases
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