Concise reports
No primary association between LMP2 polymorphisms and extraspinal
manifestations in spondyloarthropathies
a I Medical Department, b Institute of Legal
Medicine, c Department of
Medical Statistics and Documentation, d Johannes Gutenberg University Mainz, Germany
Correspondence to: Dr T Höhler, I Medizinische Klinik und Poliklinik, Johannes Gutenberg-Universität Mainz, Langenbeckstr 1, 55101 Mainz, Germany.
Accepted for publication 1 October 1997
OBJECTIVE
To investigate the potential role of the
HLA-linked LMP2 (low molecular weight protein) gene polymorphisms in
conjunction with DR4 and DR7 on extraspinal disease manifestations in
HLA-B27 positive patients with spondyloarthropathy.
METHODS172 patients with spondyloarthropathy, 46 healthy, HLA-B27 positive blood donors, and 99 unrelated controls were
typed for HLA-class I and II antigens. LMP2 alleles were determined by
polymerase chain reaction and subsequent restriction enzyme digestion.
RESULTSThere were statistically non-significant
increases of DR4 and DR7 in spondyloarthropathy subjects. However these
differences did not relate to specific extraspinal manifestations.
There were no significant differences in the LMP2 genotype distribution
in the disease groups. All differences in LMP2 genotype frequencies disappeared when correcting for DR4, which was in linkage
disequilibrium with the LMP2B allele.
CONCLUSIONSThere is no independent association
between LMP2 genotypes and the occurrence of uveitis or peripheral
arthritis in HLA-B27 positive subjects with spondyloarthropathy. DR4
and DR7 do not contribute to these disease manifestations.
© 1997 by Annals of the Rheumatic Diseases
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