Extended reports
ICAM-1, E-selectin, and TNF 
expression in labial salivary
glands of patients with rheumatoid vasculitis
a Hôpital Calmette, Lille, France:
Department of Rheumatology , b Department of Pathology C
Correspondence to: Pr René-Marc Flipo, Department of Rheumatology, Hôpital Roger Salengro, CHRU, 59037 Lille cedex, France.
Accepted for publication 11
October 1996
OBJECTIVE
To assess the expression of ICAM1,
VCAM1, E-selectin, CD44, and TNF 
in labial salivary glands of
patients with rheumatoid vasculitis.
METHODSLabial salivary glands from six patients
with rheumatoid vasculitis before and after treatment, six aged matched
rheumatoid arthritis patients without clinical evidence of rheumatoid
vasculitis, 10 patients with primary Sjögren syndrome, 10 patients with rheumatoid arthritis and proven secondary Sjögren
syndrome, and six controls were tested with specific antibodies.
RESULTSICAM1, E-selectin, and TNF were
significantly expressed in endothelial cells and perivascular cellular
infiltrate only in rheumatoid vasculitis before treatment.
CONCLUSIONSThe expression of ICAM1, E-selectin,
and TNF allows an assessment of the activity of the vasculitic
process in rheumatoid vasculitis. Labial salivary gland biopsy findings
in patients with rheumatoid arthritis and visceral vasculitis without
purpura or neuropathy (that is, mesenteric, coronary, or cerebral
vasculitis) would be of interest and are examples where labial salivary
gland tissue is more accessible than the affected tissue.
© 1997 by Annals of the Rheumatic Diseases
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