Ann Rheum Dis 1997;56:17-21 ( January )

Extended reports

Growth in infancy and bone mass in later life Cyrus Cooper,^a Caroline Fall,^a Peter Egger,^a Richard Hobbs,^b Richard Eastell,^c David Barker^a

^a MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom , ^b Department of Nuclear Medicine, Hertford County Hospital, Hertford, United Kingdom, ^c Clinical Sciences Centre, Northern General Hospital, Sheffield, United Kingdom

Correspondence to: Dr Cyrus Cooper, MRC Environmental Epidemiology Unit, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD.

Accepted for publication 30 September 1996

OBJECTIVETo examine the association between weight in infancy and bone mass during the seventh decade of life in a population based cohort for which detailed birth and childhood records were preserved.
METHODS189 women and 224 men who were aged 63-73 years and were born in East Hertfordshire underwent bone densitometry by dual energy x ray absorptiometry. Measurements were also made of serum osteocalcin and urinary excretion of type 1 collagen cross linked N-telopeptide.
RESULTSThere were statistically significant associations between weight at 1 year and bone mineral content (but not bone mineral density) at the spine (P < 0.02) and femoral neck (P < 0.01) among women, and spine (P < 0.03) among men. Although serum osteocalcin was negatively correlated with bone mineral density at both sites among men and women, infant weight was not significantly associated with either biochemical marker of bone turnover.
CONCLUSIONSThese data confirm our previous observations that growth in infancy is associated with skeletal size in adulthood, and suggest that skeletal growth may be programmed during intrauterine or early postnatal life.

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© 1997 by Annals of the Rheumatic Diseases
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